骨髓脂肪组织与疾病相关性及机制的研究进展

骨强度不仅与骨密度(BMD)、骨微结构相关,还受骨髓微环境的影响。骨髓脂肪组织(MAT)与骨小梁、造血细胞、神经血管组织共同存在于骨髓腔中,对骨重建、骨髓造血、维持骨髓微环境的稳定起重要作用。近年研究表明,MAT可通过分泌脂联素等细胞因子参与介导代谢性疾病、血液系统肿瘤、癌症等疾病的发生发展,为疾病预防、治疗及监测提供了新的思路。本文拟对MAT生物学特性、影像学测量方法、MAT与疾病相关性及可能的作用机制予以综述。     

A Novel Nomogram to Identify Candidates for Extended Pelvic Lymph Node Dissection Among Patients with Clinically Localized Prostate Cancer Diagnosed with Magnetic Resonance Imaging-targeted and Systematic Biopsies

Background

Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.

Aortic flow after valve sparing root replacement with or without neosinuses reconstruction

Objectives

This study applied advanced 4-dimensional flow magnetic resonance imaging processing to assess differences in aortic flow dynamics after valve sparing root replacement, with and without reconstruction of the Valsalva sinuses.

Identifying the optimal inlet for antegrade tibial intramedullary nailing via magnetic resonance imaging

IntroductionTibial shaft fractures treated with antegrade rigid tibial intramedullary nailing has been supported worldwide. However, the optimal inlet for nailing is still controversial. Practically, varied inlets may significantly affect the tibial alignment. This retrospective study intended to utilize magnetic resonance imaging (MRI) to investigate the optimal inlet for antegrade tibial nailing.MethodsMRIs of 100 consecutive adult patients (50 men and 50 women, average 27 years) were used in this study. All patients had MRIs for meniscus or knee ligament injuries. There were no fractures or prior bony anomalies. The center of the tibial width (TW) at the level of the tibial tubercle (TT) was considered the optimal inlet and was positioned on the axial view of the MRIs. Various related anatomic landmarks were investigated concomitantly. All parameters were compared statistically.ResultsThe medial edge of the patellar tendon (PT) was 55% from the lateral end of the TW. The apex of the TT was 38% from the lateral end of the TW. The lateral edge of the PT was 19% from the lateral end of the TW. The TT was 2.5 cm distal to the tibial articular surface. The PT width was 2.3 cm. Except for the TW, the distance from the TT to the articular surface, and PT width between genders (p < 0.001), all other parameters showed no statistical significance (p > 0.05).ConclusionsThe optimal inlet for antegrade rigid tibial intramedullary nailing may be at a site 3 mm laterally to the medial edge of the PT. There are normally no differences for the nail inlet between men and women. The PT splitting approach for nail insertion may require modification.     

Ultrasound Bone Fracture Sensing and Data Communication: Experimental Results in a Pig Limb Sample

Approximately 6.3 million fractures occur each year in the United States alone. Accurately monitoring the progression of fracture healing is essential to be able to advise patients when it is safe to return to normal activity. The most common method used to confirm and monitor fracture healing is the acquisition of multiple radiographic images over the many months required for healing. This imaging method uses large expensive equipment and exposes patients to high levels of ionizing radiation. In the study described here, we tested another technology for monitoring fracture healing that could minimize the need for multiple radiographic images. We tested a piezoelectric transducer fixed to the surface of a bone that uses electromechanical impedance spectroscopy to measure simulated fractures and transmits the measurement data to an acoustic receiver located externally on the skin surface.